I have said in my lag post much the same. All NPC once you enter their area in the catacombs are un responsive. If I quit at the exit gate can log in and then operate gate and move into the catacombs part, game operates as normal. It is exactly the same for RoF2, titanium, new models on or off, MQ2 loaded or unloaded.
Cheers
Feardem (Jim)